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In contrast with mouse thymocytes, mouse ES cells comprise higher ranges of total genomic H3K4me3 and have higher H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 46 In settlement with this, world decreases in H3K4me3 levels happen during retinoic acid (RA)-induced differentiation of mouse ES cells 47 As well as, there are dynamic modifications in H3K4me3 profiles at specific sets of genes during ES cell differentiation.
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